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    • 专利摘要:
    The present invention relates to a device for applying a composition for topical treatment of an epidermal tissue, comprising a cap adapted to render the device liquid-tight. In a further aspect, the present invention relates to a use of this device for the topical treatment of (biotin-dependent) nail dystrophy and onychoschizia, onychomycosis, onychophagia or nail biting, thumb sucking, acne, rosacea, age or pigmentation spots, vitiligo or psoriasis. In a final aspect, the present invention relates to a composition suitable for use in the above mentioned device.
    公开号:BE1022296B1
    申请号:E2015/5048
    申请日:2015-02-02
    公开日:2016-03-14
    发明作者:Bart Rossel
    申请人:Oystershell Nv；
    IPC主号:
    专利说明:

    DEVICE FOR THE TOPICAL TREATMENT OF EPIDERAL TISSUE AND COMPOSITIONS FOR THIS
    TECHNICAL DOMAIN
    The invention relates to a device for topically applying a composition to epidermal tissue, wherein the composition is suitable for the treatment of epidermal disorders, such as (biotin-dependent) nail dystrophy and onychoschizia, onychomycosis, onychophagia or nail biting, thumb sucking, acne, rosacea, age or pigmentation spots, vitiligo or psoriasis. The invention also relates to compositions suitable for use in such devices.
    BACKGROUND ART
    In a local epidermal condition, such as (biotin dependent) nail dystrophy and onychoschizia, onychomycosis, onychophagia or nail biting, thumb sucking, acne, rosacea, age or pigmentation spots, vitiligo or psoriasis, it is important to have a composition intended for the treatment of that condition. can be applied very accurately to the epidermal tissue to be treated, without coming into contact with other, untreatable epidermal tissue, since the composition on it can in some cases cause adverse or undesirable effects. The manual application of the composition, for example in the form of emulsions, gels, ointments (creams), pastes or patches, is not always accurate and moreover the composition comes into contact with the fingers and / or hand of the applicator, which produce unwanted effects.
    A number of devices for the local topical treatment of epidermal tissue have already been described in NL 2003 786, WO 2004 096447, WO 2013 039557 and BE 2010 0520, without the applicator contacting the composition. In general, these devices comprise a supply container or container that can be handled by a user and which comprises the composition for treatment, and on the other hand an applicator piece or applicator element connected to the supply container and with which the composition is applied to the epidermal tissue.
    It is important that evaporation and / or leakage of the composition from the device is minimized. After all, leakage and evaporation results in loss of the composition, which often contains expensive active components, and leads to the applicator piece drying out. The latter means that a consistent, even and accurate deposition of the composition cannot always be guaranteed over time. Furthermore, evaporation can also cause a change in the rheological properties of the composition in the storage container, ie the composition becomes more viscous, which makes the flow of the composition from the storage container to the applicator piece more difficult and can therefore no longer be applied, which can be applied again. leads to a loss of the composition.
    It is the object of the present invention to provide such a sealing cap for a device for the topical treatment of epidermal tissue, so that the device exhibits minimal leakage / evaporation of the composition.
    SUMMARY OF THE INVENTION
    It is an object of the present invention to find a solution to at least some of the above problems by providing a device for applying a topical treatment of epidermal tissue, for example for the treatment of skin and / or nail disorders, comprising: an elongated housing comprising a closed proximal end and an at least partially open distal end having a shape such that the device can be held at the distal end by a user with the thumb and at least one other finger of the same hand; a storage container accommodated in the house for assembly; an applicator piece provided at the distal end of the housing, comprising an applicator tip, which applicator tip extends through the applicator piece into the storage container of the elongated housing and thus contacts the assembly; and a detachable sealing cap for protecting the application tip, characterized in that the sealing cap is adapted for the liquid-tight sealing of the applicator piece.
    This has the advantage that the device exhibits minimal evaporation / leakage of the composition when the sealing cap is mounted on the device.
    In a second aspect, the invention relates to a use of a device according to the present invention for the topical treatment of (biotin-dependent) nail dystrophy and onychoschizia, onychomycosis, onychophagia or nail biting, thumb sucking, acne, rosacea, age or pigmentation spots, vitiligo or psoriasis. The device allows accurate and local application of the composition designated for treatment on the epidermal tissue, which is advantageous in view of the nature of the conditions.
    In a final aspect, the invention relates to a composition suitable for inclusion in a storage container of a device according to the present invention, characterized in that the composition comprises the following components: 0.001-20% by weight of an active ingredient for the above-mentioned topical treatments; 50-99 weight percent of a solvent; 0.1-20 weight percent of an additive; wherein the sum of active ingredient, solvent, additive and others equals 100% by weight of the total composition.
    DESCRIPTION OF THE FIGURES
    Figure 1 shows a perspective drawing of a device according to the present invention.
    Figure 2 shows a perspective drawing of a user who applies the device according to Figure 1 to a nail surface.
    Figure 3 shows a cross section (A) and side section (B) of the device according to Figure 1.
    Figure 4 shows a cross-section of the sealing cap according to Figure 1.
    In the figures, corresponding parts are designated with the same reference numerals as much as possible.
    DETAILED DESCRIPTION
    The invention relates to a device for applying a composition for a local topical treatment of epidermal tissue with minimal evaporation / leakage of the composition from the device, when a closure cap is mounted on the device.
    Unless defined otherwise, all terms used in the description of the invention, including technical and scientific terms, have the meaning as generally understood by those skilled in the art of the invention. For a better assessment of the description of the invention, a number of terms are explicitly explained. "A", "de" and "het" in this document refer to both the singular and the plural unless the context clearly assumes otherwise. For example, "an additive" means one or more than one additive.
    The citation of numerical intervals by the end points includes all integers, fractions and / or real numbers between the end points, including these end points.
    In a first aspect, the invention relates to a device for applying a composition for a topical treatment of an epidermal tissue, for example for the treatment of skin and / or nail disorders, comprising: an elongated housing provided with a closed proximal end and a at least partially open distal end having a shape such that the device can be held at the distal end by a user with the thumb and at least one other finger of the same hand; a storage container accommodated in the house with the composition; an applicator piece provided at the distal end of the housing, comprising an applicator tip, which applicator tip extends through the applicator piece into the storage container of the elongated housing and thus contacts the assembly; and a detachable sealing cap for protecting the application tip, characterized in that the sealing cap is adapted for the liquid-tight sealing of the applicator piece.
    The term "composition" is used herein as a synonym for "product" or "agent". The term "epidermal tissue" as used herein refers not only to human skin and / or finger and / or toenails, but also includes similar structures present in animals, such as animal skin, fur, animal nails, hooves, claws, etc.
    By the term "liquid-tight" is meant that a minimum leakage of the composition to the applicator piece occurs in a maximum of 5% of the cases when the sealing cap is mounted on the device. In a further preferred embodiment there is a minimum leakage in maximum 3%, more preferably in maximum 1% and most preferably in maximum 0.1% of the cases. By the term "minimum leakage" is meant that a maximum of 5% of the total composition leaks into the storage container from the applicator piece when the sealing cap is mounted on the device. In a further preferred embodiment maximum 3%, more preferably maximum 1% and most preferably maximum 0.1% of the total composition in the storage container that leaks from the applicator piece when the sealing cap is mounted on the device.
    The current device allows a composition to be applied to epidermal tissue easily, quickly and in a user-friendly manner. This is important since the success of a treatment depends to a large extent on the compliance of the patient.
    In a preferred embodiment, the composition has a viscosity preferably between 1 mPa s and 1000 mPa s, more preferably between 10 mPa s and 800 mPa s, even more preferably between 50 mPa s and 600 mPa s, even more preferably between 100 mPa s and 400 mPa s and most preferably between 150 mPa s and 250 mPa s.
    Too high a viscosity ensures that the composition cannot flow through the pores of the application tip and therefore cannot be applied in a topical treatment. Too low a viscosity, on the other hand, ensures that the composition is not retained by the application tip and that the composition can flow out of the housing. A composition with a too low viscosity will also cause problems with the topical treatment. For example, the composition with too low a viscosity will spread over a large surface, which makes precise application of the composition difficult or impossible.
    In a preferred embodiment, housing, storage container, applicator piece and sealing cap are made of polymers and produced via injection molding in a mold.
    In a second aspect, the invention relates to a device in which the sealing cap is adapted for sealing the applicator piece substantially in a gas-tight manner.
    By the term "gas-tight" it is meant that a minimal evaporation of the composition on the applicator piece occurs in a maximum of 5% of the cases when the sealing cap is mounted on the device. In a further preferred embodiment, there is a minimum evaporation in maximum 3%, more preferably in maximum 1% and most preferably in maximum 0.1% of the cases. By the term "minimum evaporation" is meant that a maximum of 5% of the total composition in the supply container evaporates on the applicator piece when the sealing cap is mounted on the device. In a further preferred embodiment, there is a maximum of 3%, more preferably a maximum of 1% and most preferably a maximum of 0.1% of the total composition in the storage container that evaporates on the applicator piece when the sealing cap is mounted on the device.
    In a preferred embodiment, the aforementioned sealing cap consists of: a first housing, provided with a closed distal end and an open proximal end, which, when the sealing cap is mounted on the device, comprises the applicator piece at least in part and of which the open proximal end is provided of a connection mechanism for engaging the applicator piece; and a second housing, also provided with a closed distal end and an open proximal end, which is accommodated by the first housing and which, when the closure cap is mounted on the device, includes the application tip at least partially and which has the open proximal end provided is of a connecting mechanism to engage on or around the application tip.
    With these two housings, the sealing cap provides double protection for the application tip, which allows to minimize evaporation and leakage of the composition.
    In a preferred preferred embodiment, the connecting mechanism of the second housing according to the present invention comprises grooves that fit into recesses present on or around the application tip.
    In a preferred embodiment, a device according to the present invention, in cross section through the device, for example through a connection point (4) (Fig. 1-3), essentially has a trapezoidal shape. This shape has the advantage that when the device is on a horizontal surface, it cannot start rolling over this surface when a user comes into contact with it, for example when a force is exerted on it. Furthermore, the closure of the sealing cap on the housing is unambiguous and simple due to this shape, which increases the usability of the device. Finally, this shape also simplifies the assembly of the device, i.e. because the housing, storage container, applicator piece and sealing cap can be mounted to each other in an unambiguous manner. This allows the assembly of the various components of the device to be automated, which increases the production efficiency of the device.
    In a further aspect, the invention relates to a use of a device according to one of the preceding claims for the topical treatment of (biotin-dependent) nail dystrophy and onychoschizia, onychomycosis, onychophagia or nail biting, thumb sucking, acne, rosacea, age or pigmentation spots, vitiligo or psoriasis.
    Devices according to the invention are suitable, for example, for the treatment, prevention and after-treatment of onychomycosis caused by dermatophytes, yeasts or fungi or mixed infections. Age or pigmentation spots may include melasma, birthmarks, freckles, etc.
    Furthermore, devices according to the invention can be used, for example, for the treatment, prevention, after-treatment or supportive treatment of nail diseases, the treatment of diseases in areas around the nails (so-called periungual diseases), nail care, skin diseases, as well as skin care. Moreover, the present invention also relates to the use of a device according to the invention for the treatment of hooves, claws, nails, skin or fur of animals.
    The frequency of application of the device according to the invention is partly determined by the nature and location of the condition. In general, applying one, two or three times a day is sufficient. The device is applied directly to the skin, nail, hoof, coat or claw.
    In a following aspect, the invention relates to a composition suitable for incorporation into a storage container of a device according to the invention, the composition comprising the following components: 0.001-20% by weight of an active ingredient for the above-mentioned topical treatments; 50-99 weight percent of a solvent; 0.1-20 weight percent of an additive; wherein the sum of active ingredient, solvent, additive and others equals 100% by weight of the total composition.
    Optionally, other components may be present in the composition. The sum of the components is equal to 100% by weight of the total composition.
    In a preferred embodiment, the composition for use in the topical treatment of nail dystrophy and onychoschizia, onychomycosis, onychophagia or nail biting, thumb sucking, acne, rosacea, age or pigmentation spots, vitiligo or psoriasis may or may not be biotin dependent.
    In a preferred embodiment of a composition according to the present invention, the active ingredient is selected from biotin or from the group of keratin derivatives; amino acids; carboxylic acids; ultraviolet (UV) filters; natural and / or synthetic bitters; off flavors; anti-acne drugs; melanogenesis interfering agents; post-melanogenesis bleaching agents; keratolytic ingredients; contact irritants; or any combination thereof.
    In a preferred embodiment, the composition comprises as active ingredient biotin. Biotin is also referred to as vitamin H or vitamin B8 and is present in the compositions of the present invention in an amount of 0.001-20% by weight, preferably 0.01-1% by weight, most preferably 0.05-0.1% by weight, expressed relative to the total composition.
    In another preferred embodiment, the composition comprises as active ingredient keratin derivatives. The amount of keratin derivatives are present in the composition, preferably between 0.001-20% by weight, preferably 0.01-1% by weight, most preferably 0.05-0.1% by weight, expressed relative to the total composition.
    In another preferred embodiment, the composition comprises as active ingredient an amino acid selected from the non-limitative list of cysteine, cystine, vitamin B12 or a mixture thereof. The amount of amino acids are present in the composition, preferably between 0.001-20% by weight, preferably 0.01-1% by weight, most preferably 0.05-0.1% by weight, expressed relative to the total composition.
    In another preferred embodiment, the composition comprises as an active ingredient UV filters. These serve to absorb or reflect UVA or UVB radiation from light. UV filters are preferably selected from the non-exhaustive list of octocrylene, methylene bis-benzotriazolyl tetramethylbutylphenol, bis-ethylhexyloxyphenol methoxyphenyl triazine, padimate O, sulisobenzone, homosalate, octyl methoxycinnamate, ecamsule, octisalate, avobenzone, oxybenzon, zinc oxide any combination of these.
    In another preferred form, the composition comprises as active ingredient a carboxylic acid selected from the list of acetic acid, formic acid, lactic acid, citric acid, tartaric acid, fumaric acid. Preferably the carboxylic acid is acetic acid or lactic acid. This acid helps to acidify the epidermal tissue, and preferably the nail, and makes it so inhospitable to dermatophytes. In a preferred form, the composition comprises 0.001-20% by weight of carboxylic acid, preferably 1-5% by weight, more preferably 1-3% by weight, expressed relative to the total composition. Preferably, the composition comprises 0.001-20 weight percent acetic acid, more preferably 1-3 weight percent acetic acid, expressed relative to the weight of the total composition. Preferably, the composition comprises 0.001-20% by weight of lactic acid, more preferably 1-3% by weight of lactic acid, expressed relative to the weight of the total composition.
    In another preferred embodiment, the composition comprises as active ingredient natural bitters such as citrus fruit extracts and peels such as grapefruit and / or synthetic bitters such as denatonium benzoate. Preferably, the composition comprises 0.001-20% by weight of natural and / or synthetic bitters, more preferably 2-10% by weight of natural and / or synthetic bitters, expressed relative to the weight of the total composition.
    In another preferred embodiment, the composition comprises as an active ingredient off-flavors, by which is meant flavors that can be regarded as repulsive by certain persons, such as coriander. Preferably, the composition comprises 0.001-20% by weight off-flavors, more preferably 2-10% by weight off-flavors, expressed relative to the weight of the total composition.
    In another preferred embodiment, the composition comprises as active ingredient anti-acne drugs, being anti-acne formation and / or development agents, such as plant extracts selected from the non-exhaustive list of Lavandula angustifolia (lavender), Salix alba (willow) bark extracts, Mentha piperita (peppermint) leaf extracts, Simmondsia chinensis (jojoba) seed oil, Euterpe oleracea (acai berry) fruit oil, etc. or any combination thereof.
    In another preferred embodiment, the active ingredient composition comprises melanogenesis interfering agents, which means agents that suppress or block the production of the natural pigment melanin selected from the non-exhaustive list of hydroquinone (1,4-dihydroxybenzene) or hydroquinone derivatives such as arbutin (hydroquinone-0- / 3-D-glucopyranoside) or deoxyarbutin, kojic acid (5-hydroxy-2-hydroxymethyl-4H-pyran-4-one) or derivatives thereof, azelaic acid (1,7-heptanedicarboxylic acid), flavonoids such as aloesine, hydroxystilbene derivatives (e.g., resveratrol) or licorice extracts (e.g., glabiridine), as well as vitamin E, vitamin B or vitamin C or derivatives thereof, or any combination thereof.
    In another preferred embodiment, the composition comprises as active ingredient post-melanogenesis bleaching agents, by which are meant means the transport of melanin from the melanocytes, ie the cells that produce melanin, to the keratinocytes, ie cells that are in the epidermis, the outer layer from the skin, inhibit selected from the non-exhaustive list of soy milk or soy bean extracts, niacinamide, lectins or derivatives thereof, or any combination thereof.
    In another preferred embodiment, the active ingredient composition comprises keratolytic ingredients, by which are meant agents which have an exfoliating effect on the epidermal tissue, ie which release or soak the epidermis selected from the non-limitative list of linoleic acid, 8-hexadecene-1, 16-dicarboxylic acid, retinoic acid, salicylic acid or lactic acid or a combination thereof or of alpha-hydroxy acids (such as glycolic acid, acetic acid, lactic acid, citric acid) or complexes thereof.
    In another preferred embodiment, the composition as an active ingredient comprises contact irritants, by which are meant agents that exert an irritating effect on epidermal or mucosal tissue selected from the non-exhaustive list of capsaicin, peppermint, menthol or eucalyptol. Preferably, the composition comprises 0.001-20% by weight of contact irritants, more preferably 1-5% by weight of contact irritants, expressed relative to the weight of the total composition.
    More than one active ingredient can be employed in the composition, the above numerical preferred intervals being valid per active component present in the composition.
    The present composition may further comprise a solvent that has a sufficiently low vapor pressure so that it can evaporate quickly after application, has a high affinity for the epidermal tissue so that it penetrates easily, is a good solvent for the active component and additives that are not harmful and is furthermore compatible with the material of the device.
    This solvent is preferably selected from acetone, ethanol, isopropyl alcohol or from the group of molecules that satisfy the following structural formula (I): R ^ O-R2, where R1 is a straight or branched alkyl group of one to six and preferably one to three carbon atoms, and R 2 is a group derived from an organic acid or from hydroxy acid such as but not limited to acetic acid, lactic acid, formic acid.
    In a preferred embodiment of a topical composition according to the invention, said solvent, preferably of the above formula (I), has a Log P comprised between 0 and 1.
    In another preferred embodiment, the invention provides a topical composition wherein said solvent has a vapor pressure (vapor pressure) at 20 ° C that is lower than 5 mm Hg, and preferably lower than 4 mm Hg.
    The aforementioned solvent is preferably present in the present invention in an amount of 50-99% by weight and preferably 60-90% by weight relative to the weight of the total composition. Water is not counted as a solvent.
    In a preferred embodiment of a composition according to the present invention, the additive is selected from the group of penetration enhancing agents; lipids such as ceramides, phospholipids, squalane and squalene, glycerides, fatty acids, waxes, esters, cholesterol and other sterols, and fatty alcohols, or a mixture thereof; film formers; moisturizers; preservatives; or any combination thereof.
    In a preferred embodiment, the composition comprises as an additive an penetration-promoting agent, by which is meant an agent that promotes the penetrating power of the composition, preferably the active component. The penetration-promoting agent is preferably selected from the group of glycols, monoethers of glycols, diethers of glycols, dimethylsulfoxide, caprolactam, dimethylisosorbitol, pentylene glycol isopropylidene glycerol, glycerol, dimethylimidazolidinone, N-methylpyrrolidone, pyrrolidone, pyrrolidone, pyrrolidone, pyrrolidone, pyrrolidone, pyrrolidone, polyoxyethylenes, polyethylene glycol glyceryl laurate, dimethylacetamide. Preferably, the penetration-promoting agent is dimethyl sulfoxide. The penetration-promoting agent is present in a composition according to the present invention in an amount of 0.1-20% by weight, preferably 0.5-5% by weight, most preferably 1-3% by weight, expressed relative to the weight of the total composition.
    In another preferred embodiment, the composition comprises as an additive lipids selected from the non-exhaustive list of ceramides, phospholipids, squalane and squalene, glycerides, fatty acids, waxes, esters, cholesterol and other sterols, and fatty alcohols, or a mixture thereof. Preferably the lipid is a fatty alcohol. The lipids are in a composition according to the present invention in an amount of 0.1-20% by weight, preferably 1-10% by weight, most preferably 2-5% by weight, expressed relative to the weight of the total composition.
    In another preferred embodiment, the composition comprises film formers as an additive. Film formers are added to the composition to ensure that, after the solvent has evaporated, the active ingredient remains on the epidermal tissue and thus has time to penetrate. For this, a water-insoluble substance is preferably selected from the list of polyurethane derivatives, dimethicone, butyl ester of polyvinyl methyl ether and malic acid copolymer, copolymers of acrylates and ammonium methacrylates, hydroxy ethyl cellulose, nitrocellulose, ethyl cellulose. Preferably, in a composition according to the invention, 0.1-20% by weight, more preferably 0.5-5% by weight and most preferably 1-3% by weight of film former are present, expressed in relation to the total weight of the composition.
    In another preferred embodiment, the composition comprises as an additive moisturizers such as water and / or emollients that attract water. The presence of water and / or an emollient helps to hydrate the epidermal tissue. Most preferably, the composition as a moisturizing agent comprises an emollient, preferably selected from the list of propylene glycol, hexylene glycol, butylene glycol, glyceryl triacetate, aloe vera gel, urea, vinyl alcohol, glycerol, sugar alcohols and polyols, sorbitol, xylitol , maltitol, polydextrose, quillaia or mixtures thereof. Preferably, a composition according to the invention contains 0.1-20% by weight, more preferably 1-5% by weight, of moisturizing agents, expressed in relation to the total weight of the composition.
    In another preferred embodiment the composition comprises as additive preservatives. Since the composition, as well as the applicator piece, according to the invention can be brought into contact for a long time with a (potentially) infected surface, it is advantageous for the composition to be adequately stored. To that end, the composition preferably comprises one or more preservatives. A suitable preservative may be selected from the list of ethylenediaminetetraacetic acid (EDTA), fenylmercuriboraat, phenylmercuric acetate, phenylmercuric nitrate, thiomersal, methyl parahydroxybenzoate, propyl parahydroxybenzoate, ethylparahydroxy benzoate, butyl parahydroxybenzoate, benzoic acid, sodium benzoate, calcium benzoate, potassium sorbate, calcium sorbate, sodium sorbate, sorbic acid, chlorocresol, benzyl alcohol, chlorobutanol, ethanol, phenylethyl alcohol, phenoxyethanol, glycerol, propylene glycol, butanediol, pentane diol, hexane diol, heptane diol, octane diol, nonane diol, decane diol, caprylyl glycol, sucrose, bronopol, hexamethylene tetramine, nitrate sodium , butylene glycol. In a preferred form, benzoic acid is present in a composition according to the invention. In another preferred form, caprylyl glycol is present in a composition according to the invention. The preservative is preferably provided in an amount of 0.1-20% by weight, more preferably in 0.5-5% by weight, most preferably 1-3% by weight expressed with respect to the total composition.
    More than one additive can be employed in the composition, the above numerical preferred intervals being valid per additive present in the composition.
    In a preferred embodiment, the composition of the present invention is a topical composition for treating onychomycosis, and the composition comprises: - 0.001-10% by weight of an active ingredient selected from the list of biotin, keratin derivatives, amino acids or a mixture thereof; - 0.1-20% by weight of lipids as an additive selected from the list of triglycerides, fatty acids, ceramides, squalane, squalene, sterols, waxes and fatty alcohols, or a mixture thereof; 1-10% by weight of an penetration-promoting agent as an additive; - supplemented with solvents, film formers, carboxylic acids, preservatives and / or moisturizing agents; - wherein the sum of active ingredient, penetration-promoting agent, lipids and other components is equal to 100% by weight of the total composition.
    In the following, the invention is described a.d.h.v. non-limiting examples illustrating the invention, and which are not intended or may be interpreted to limit the scope of the invention.
    EXAMPLES
    The invention will now be elucidated with reference to the accompanying drawings of an arbitrary exemplary embodiment, to which the invention is not limited.
    Figure 1 shows a device (1), comprising an elongated housing (2), which can easily be taken in the hand, with a removable closure cap (3) on it that touches the housing at a connection point (4).
    Figure 2 shows how a user can engage the housing of the device and how an applicator piece (10) becomes visible when the sealing cap is removed. The distal portion of the applicator piece (11) axially positions an application tip, the distal portion (9) of which is used to apply a composition to epidermal tissue, such as, for example, a nail surface in this case.
    3, A and B, shows a device (1), comprising an elongated housing (2) with a removable closure cap (3) on top of it. The closure cap is provided with a connection mechanism (4) for mounting / disassembly on / of the housing, for example by securing / loosening a groove on the proximal part of the closure cap in / of a recess on the distal part of the housing . In a preferred embodiment, an additional top layer (5) in a different material is provided on the housing (2) and the sealing cap (3) at certain locations, which provides better grip during use of the device.
    The housing (2) accommodates a storage container (6), which comprises a composition according to the present invention. The housing with storage chamber disters into an applicator piece (10), which is provided with a specific mechanism (13) to be attached to the housing. In a preferred embodiment, the applicator piece (10) is mounted on the housing (2) via a groove on the outer wall of the proximal portion of the applicator piece (12) that is attached in a shallow recess on the inner wall of the housing (2).
    The distal portion (11) of the applicator piece (10) axially positions an absorbent element, the application tip (7), consisting of a liquid-absorbent material. The proximal portion (8) of the applicator tip (7) is in contact with the contents of the reservoir (6) and can bring the composition via capillary action to the distal portion of the applicator tip (9) where the actual application of the composition on epidermal tissue. In a preferred form, the distal portion of the application tip is designed such that it has a pointed end for very accurate applications, for example on the skin, but also a linear portion, which gives the possibility to deposit wider layers of the composition, preferably for deposits on a nail. The applicator piece is protected by the sealing cover.
    The closure casing comprises a first housing (3) provided with a closed distal end and an open proximal end which, when the closure cap is mounted on the device, via connection mechanism (4), comprises at least partially the applicator piece. Furthermore, the closure casing comprises a second housing (14), also provided with a closed distal end and an open proximal end, which is accommodated by the first housing and which, when the closure cap is mounted on the device, includes the application tip at least in part and the open proximal end of which is provided with a connection mechanism (15) for engaging around the application tip, preferably on the distal portion of the applicator piece that positions the application tip. In a preferred embodiment of this connecting mechanism (15), there are grooves present on the proximal inner wall of the second housing that can be attached to recesses present on the distal outer wall of the applicator piece (11).
    Figure 4 shows a closure cap, with first (3) and second housing (14), with in a preferred embodiment, grooves (16) on the proximal inner wall of the second housing that can be attached to recesses present around the application tip, preferably on the the portion of the applicator piece that positions the application tip. EXAMPLE 1: compositions for local epidermal treatments
    The present invention can use the following compositions; these examples are not limitative of the present invention:
    Composition 1:
    This example relates to a composition for the treatment of onychomycosis which is applied with a device according to the present invention and which comprises per 100 g: biotin 0.05 g acrylate / ammonium methacrylate copolymer 0.5 g acetic acid 1.0 g lanolin derivatives (lipid) 1 0 g glycerol 1.0 g polyoxypropylene 15-stearyl ether (lipid) 3.0 g pentylene glycol 3.0 g dimethyl sulfoxide 3.0 g ethyl acetate 87.45 g
    Composition 2:
    This example relates to a composition for treating nail biting which is applied with a device according to the present invention and which comprises per 100 g: biotin 0.05 g citrus extract 1.0 g eucalyptol 2.0 g dimethyl sulfoxide 3.0 g ethyl lactate 25, 0 g denatonium benzoate 4.0 g acrylate / ammonium methacrylate copolymer 1.0 g isopropanol 63.95 g
    It is believed that the present invention is not limited to the embodiments described above and that some modifications or changes can be added to the described examples without re-evaluating the appended claims.
    Reference figures 1: device 2: housing 3: sealing cap / first housing of sealing cap 4: connecting point / connecting mechanism of sealing cap to housing 5: top layer present on housing and sealing cap 6: storage container 7: application tip 8: proximal part of application tip 9: distal part of application tip 10: applicator piece 11: distal part of applicator piece 12: proximal part of applicator piece 13: connecting mechanism of applicator piece to housing 14: second housing of sealing cap 15: connecting mechanism of second housing to distal part of applicator piece 16: grooves of connecting mechanism of second housing
    权利要求:
    Claims (14)
    [1]
    CONCLUSIONS
    Device for applying a composition for topical treatment of an epidermal tissue, for example for the treatment of skin and / or nail disorders, comprising: an elongated housing provided with a closed proximal end and an at least partially open distal end having a shape such that the device can be held at the distal end by a user with the thumb and at least one other finger of the same hand; a storage container accommodated in the house for assembly; an applicator piece provided at the distal end of the housing, comprising an applicator tip, which applicator tip extends through the applicator piece into the storage container of the elongated housing and thus contacts the assembly; and a detachable closure cap for protecting the application tip, characterized in that the closure cap is adapted to seal the applicator piece in a liquid-tight and gas-tight manner, so that a minimum leakage of the composition to the applicator piece occurs in a maximum of 5% of the cases, when the sealing cap is mounted on the device, and so that a minimal evaporation of the composition on the applicator piece occurs in a maximum of 5% of the cases, when the sealing cap is mounted on the device, the term "minimum leakage" being understood to mean that maximum 5% of the total composition in the supply container leaks from the applicator piece when the sealing cap is mounted on the device, and the term "minimum evaporation" means that a maximum of 5% of the total composition in the supply container evaporates on the applicator piece when the closure cap is mounted on the device.
    [2]
    Device according to claim 1, characterized in that the composition has a viscosity between 1 mPa s and 1000 mPa s.
    [3]
    Device as claimed in any of the foregoing claims 1 to 2, characterized in that the closing cap consists of: a first housing provided with a closed distal end and an open proximal end which, when the closing cap is mounted on the device, applicator piece comprises at least in part and whose open proximal end is provided with a connecting mechanism to engage the applicator piece; and a second housing, also provided with a closed distal end and an open proximal end, which is accommodated by the first housing and which, when the closure cap is mounted on the device, includes the application tip at least partially and which has the open proximal end provided is of a connecting mechanism to engage on or around the application tip.
    [4]
    Device as claimed in claim 3, characterized in that the connecting mechanism of the second housing comprises grooves which fit in recesses present on or around the application tip.
    [5]
    A composition suitable for inclusion in a storage container of a device according to any one of claims 1 to 4, characterized in that the composition comprises the following components: 0.001-20% by weight of an active ingredient for said topical treatments; 50-99 weight percent of a solvent; 0.1-20 weight percent of an additive; wherein the sum of active ingredient, solvent, additive and others equals 100% by weight of the total composition.
    [6]
    Composition according to claim 5, for use in the topical treatment of (biotin-dependent) nail dystrophy and onychoschizia, onychomycosis, onychophagia or nail biting, thumb sucking, acne, rosacea, age or pigmentation spots, vitiligo or psoriasis.
    [7]
    Composition according to claim 5 or 6, characterized in that the aforementioned active ingredient is selected from biotin or from the group of keratin derivatives; amino acids; carboxylic acids; ultraviolet (UV) filters; natural and / or synthetic bitters; off flavors; anti-acne medicines; melanogenesis interfering agents; post-melanogenesis bleaching agents; keratolytic ingredients; contact irritants; or any combination thereof.
    [8]
    The composition of claim 7, wherein said carboxylic acid is selected from the list of acetic acid, formic acid, lactic acid, citric acid, tartaric acid, fumaric acid.
    [9]
    A composition according to any one of the preceding claims 5 to 8, characterized in that the solvent is selected from acetone, ethanol, isopropyl alcohol or from the group of esters that satisfy the following structural formula (I): R ^ O-R2, wherein R 1 is a straight or branched alkyl group with one to six and preferably one to three carbon atoms, and R 2 is a group derived from an organic acid or from hydroxy acid such as, but not limited to, acetic acid, lactic acid, formic acid.
    [10]
    Composition according to any one of the preceding claims 5 to 9, characterized in that the aforementioned additive is selected from the group of penetration-promoting agents; lipids such as ceramides, phospholipids, squalane and squalene, glycerides, fatty acids, waxes, esters, cholesterol and other sterols, and fatty alcohols, or a mixture thereof; film formers; moisturizers; preservatives; or any combination thereof.
    [11]
    Composition according to claim 10, characterized in that the aforementioned penetration-promoting agent is selected from the group of glycols, mono-ethers of glycols, diethers of glycols, dimethylsulfoxide, caprolactam, dimethylisosorbitol, pentylene glycol isopropylidene glycerol, glycerol, dimethylimidazolidinone, N- methyl pyrrolidone, pyrrolidone, ethyl lactate, glycerides of C9 -C10 polyoxyethylenes, polyethylene glycol glyceryl laurate, dimethylacetamide.
    [12]
    Composition according to claim 10 or 11, characterized in that the aforementioned film formers are selected from the list of polyurethane derivatives, dimethicone, butyl ester of polyvinyl methyl ether and malic acid copolymer, copolymers of acrylates and ammonium methacrylates, hydroxy ethyl cellulose, nitrocellulose , ethyl cellulose.
    [13]
    Composition according to any one of the preceding claims 10 to 12, characterized in that the aforementioned moisturizing agent is preferably selected from water and / or an emollient, wherein the emolient can be selected from the list of propylene glycol, hexylene glycol, butylene glycol, glyceryl triacetate, aloe vera gel, urea, vinyl alcohol, glycerol, sugar alcohols and polyols, sorbitol, xylitol, maltitol, polydextrose, quillaia or mixtures thereof.
    [14]
    Composition according to any one of the preceding claims 10 to 13, characterized in that said preservative is selected from the list of ethylenediaminetetraacetic acid (EDTA), phenylmercuriborate, phenylmercuriacetate, phenylmercurinitrate, thiomersal, methyl parahydroxybenzoate, propyl parahydroxybenzoate, benzoate, benzoate, benzoate, benzoate, benzoate, benzoate, benzoate, benzoate, etc. , calcium benzoate, potassium sorbate, calcium sorbate, sodium sorbate, sorbic acid, chlorocresol, benzyl alcohol, chlorobutanol, ethanol, phenylethyl alcohol, phenoxyethanol, glycerol, propylene glycol, butanediol, pentane diol, hexane diol, heptane diol, octane diol, nonane diol, decane diol, decane caprylyl glycol, sucrose, bronopol, hexamethylene tetramine, sodium nitrite, sodium nitrate, butylene glycol.
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    同族专利:
    公开号 | 公开日
    BE1022296B9|2017-12-12|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    US20050261639A1|2004-05-05|2005-11-24|Atrium Medical Corp.|Medicated ink marker|
    WO2006125442A1|2005-05-26|2006-11-30|Leo Pharma A/S|A pharmaceutical product comprising a container|
    US20110208136A1|2007-09-27|2011-08-25|Horst Sollingen|Method for applying a liquid medicinal treatment medium to an area to be treated and medicinal product|
    EP2098460A1|2008-03-08|2009-09-09|Jürgen Schmidt|Dispensing device for flowable media|
    CN112533576A|2018-06-06|2021-03-19|马克·塔科内利|Methods and kits for providing customizable onychomycosis prophylaxis treatment|
    法律状态:
    2018-02-15| FG| Patent granted|Effective date: 20160314 |
    优先权:
    申请号 | 申请日 | 专利标题
    BE20155048A|BE1022296B9|2015-02-02|2015-02-02|DEVICE FOR THE TOPICAL TREATMENT OF EPIDERAL TISSUE AND COMPOSITIONS FOR THIS|BE20155048A| BE1022296B9|2015-02-02|2015-02-02|DEVICE FOR THE TOPICAL TREATMENT OF EPIDERAL TISSUE AND COMPOSITIONS FOR THIS|
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